Paolo Carloni
Affiliation
Forschungszentrum Jülich, Germany - Research
Neurological Disease-Linked Mutations: A Multiscale Approach
Abstract
I will present applications on protein complexes and RNAs, which may demonstrate the usefulness of different simulation techniques (from QM/MM and atomistic MD to systems biology). These methods may provide insight into the mechanisms by which mutations lead to aberrant neurological processes. I will conclude by discussing our recent efforts to combine molecular and neuronal simulations to predict changes in neural spikes caused by ion channel variants.